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Lookup NU author(s): Dr Florence Burte
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.
Author(s): Bachmann J, Burté F, Pramana S, Conte I, Brown BJ, Orimadegun AE, Ajetunmobi WA, Afolabi NK, Akinkunmi F, Omokhodion S, Akinbami FO, Shokunbi WA, Kampf C, Pawitan Y, Uhlén M, Sodeinde O, Schwenk JM, Wahlgren M, Fernandez-Reyes D, Nilsson P
Publication type: Article
Publication status: Published
Journal: PLoS Pathogens
Year: 2014
Volume: 10
Issue: 4
Print publication date: 17/04/2014
Acceptance date: 06/02/2014
Date deposited: 22/05/2014
ISSN (electronic): 1553-7374
Publisher: Public Library of Science
URL: http://dx.doi.org/10.1371/journal.ppat.1004038
DOI: 10.1371/journal.ppat.1004038
PubMed id: 24743550
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