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COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups

Lookup NU author(s): Professor Carol Brayne, Professor Bloss Stephan

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Abstract

Background: A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders. Methods/Design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress. Discussion: The challenges of international consortia like COSMIC include efficient communication among members, extended use of resources, and data harmonisation. Successful harmonisation will facilitate projects investigating rates of cognitive decline, risk and protective factors for mild cognitive impairment, and biomarkers of mild cognitive impairment and dementia. Extended implications of COSMIC could include standardised ways of collecting and reporting data, and a rich cognitive ageing database being made available to other researchers. COSMIC could potentially transform our understanding of the epidemiology of cognitive ageing, and have a world-wide impact on promoting successful ageing.


Publication metadata

Author(s): Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao SF, Li J, Li X, Brayne C, Matthews FE, Stephan BCM, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LCW, Wong CHY, Fung AWT, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, COSMIC

Publication type: Article

Publication status: Published

Journal: BMC Neurology

Year: 2013

Volume: 13

Pages: 1-8

Print publication date: 06/11/2013

Date deposited: 17/06/2014

ISSN (electronic): 1471-2377

Publisher: BioMed Central Ltd

URL: http://dx.doi.org/10.1186/1471-2377-13-165

DOI: 10.1186/1471-2377-13-165


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Funding

Funder referenceFunder name
Pfizer Foundation, Madrid
Eisai
Mr. Lai Seung Hung & Mrs. Lai Chan Pui Ngong Dementia in Hong Kong Research Fund
Novartis
01/0255Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
03/0815Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
03/121/17/214Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore
06/0617Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
08/1/21/19/567Biomedical Research Council, Agency for Science, Technology and Research (A*STAR) in Singapore
1002160National Health and Medical Research Council of Australia
157125National Health and Medical Research Council of Australia
1R03 AG045474National Institute on Health/National Institute on Aging
2009BAI77B03China Ministry of Science and Technology
179805National Health and Medical Research Council of Australia
94/1562Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
98/0103Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
AG033193National Institute of Aging
350833National Health & Medical Research Council of Australia Program Grant
5P01 AG003949National Institute on Health/National Institute on Aging
6605-3954-MC[S]National Health Research Development Program of Health Canada
97/1321EFondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
973302National Health and Medical Research Council of Australia
A092077Ministry for Health, Welfare, & Family Affairs, Republic of Korea
AG08122National Institute of Aging
AG16495National Institute of Aging
G03/128Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spanish Ministry of Health, Madrid, Spain
HL93029National Heart, Lung and Blood Association
NS17950National Institute of Neurological Disorders and Stroke
P50 AG016574National Institute on Aging
N01-HC-25195National Heart, Lung and Blood Institute's Framingham Heart Study
P01 AG07232National Institute of Health/National Institute on Aging
R01AG07562National Institute on Aging, National Institutes of Health, United States Department of Health and Human Services
R01 AG034676National Institute on Aging
R01 AG037212National Institute of Health/National Institute on Aging
U01 AG006786National Institute on Aging
U01HL 096917National Heart, Lung and Blood Association

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