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Lookup NU author(s): Professor Colin Rees, Dr Peter James, Dr Richard McNallyORCiD, Dr Matthew Rutter
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Background and study aims: Adenoma detection is a key objective of colonoscopy, particularly in the context of colorectal cancer screening. The aim of this observational study was to identify the technical colonoscopy factors associated with adenoma detection. Patients and methods: The study analyzed data from the English Bowel Cancer Screening Programme. The indication for all colonoscopies was a positive fecal occult blood test. The relationships between the following colonoscopy factors and adenoma detection (one or more adenomas, advanced adenomas, right-sided adenomas, and total number of adenomas) were examined in multivariable analyses: bowel preparation quality, cecal intubation, withdrawal time, rectal retroversion, colonoscopist experience, antispasmodic use, sedation use, and start time of procedure. The following patient factors were controlled for: age, sex, body mass index, smoking, alcohol, deprivation, and geographical location. Results: A total of 31088 colonoscopies were analyzed. The following technical factors increased the relative risk of adenoma detection (P < 0.001 in multivariable analysis unless otherwise stated): cecal intubation, increased withdrawal time, higher quality bowel preparation, intravenous antispasmodic use, earlier procedure start time within a session (P = 0.018), and greater colonoscopist experience. Detection of advanced and right-sided adenomas also increased with these factors. Adenoma detection did not differ between sedated and unsedated colonoscopy (P = 0.143). Conclusion: This study demonstrated important associations between colonoscopy practice and adenoma detection. Use of intravenous antispasmodic was associated with increased adenoma detection. The effect of the start time of colonoscopy suggests that endoscopist fatigue may have a deleterious impact on adenoma detection.
Author(s): Lee TJ, Rees CJ, Blanks RG, Moss SM, Nickerson C, Wright KC, James PW, McNally RJ, Patnick J, Rutter MD
Publication type: Article
Publication status: Published
Journal: Endoscopy
Year: 2014
Volume: 46
Issue: 3
Pages: 203-211
Print publication date: 01/03/2014
Online publication date: 28/01/2014
Acceptance date: 30/09/2013
Date deposited: 03/04/2014
ISSN (print): 0013-726X
ISSN (electronic): 1438-8812
Publisher: Georg Thieme Verlag
URL: https://doi.org/10.1055/s-0033-1358831
DOI: 10.1055/s-0033-1358831
PubMed id: 24473907
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