ePrints

Proportionate Reduction in Uncertainty of Late Onset Infection in Pre-term Infants by Neutrophil CD64 Measurement

Lookup NU author(s): Professor Janet Berrington, Professor Christopher StewartORCiD, Professor Nicholas EmbletonORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

Objective: Establish howneutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT). Methods: A total of 38preterm infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curveswere generated for CD64 counts at various threshold values. Results: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%. Conclusions: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.

Publication metadata

Author(s): Berrington JE, Hearn RI, Hall C, Stewart CJ, Cummings SP, Embleton ND

Publication type: Article

Publication status: Published

Journal: Fetal & Pediatric Pathology

Year: 2014

Volume: 33

Issue: 1

Pages: 16-22

Print publication date: 01/02/2014

ISSN (print): 1551-3815

ISSN (electronic): 1551-3823

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/15513815.2013.842270

DOI: 10.3109/15513815.2013.842270

Altmetrics

Share