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Lookup NU author(s): Dr Amanda Villalvilla Garcia, Dr Rodolfo Gomez
Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.
Author(s): Villalvilla A, Gomez R, Largo R, Herrero-Beaumont G
Publication type: Review
Publication status: Published
Journal: International Journal of Molecular Sciences
Year: 2013
Volume: 14
Issue: 10
Pages: 20793-20808
Print publication date: 16/10/2013
ISSN (electronic): 1422-0067
Publisher: MDPI AG
URL: http://dx.doi.org/10.3390/ijms141020793
DOI: 10.3390/ijms141020793
