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Neuromuscular toxicology of the venom of Collett's snake (Pseudechis colletti): A histopathological study

Lookup NU author(s): Tracey DaveyORCiD, Emeritus Professor John Harris

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Abstract

Introduction: A bite by Collett's snake, (Pseudechiscolletti) can cause rhabdomyolysis in human victims but no signs of neurotoxicity. The pathology of muscle and peripheral nerve has not been described previously. In this study we investigated neuromuscular toxicity in rats. Methods: The venom was inoculated subcutaneously into the anterolateral aspect of one hindlimb of adult rats at a dose replicating that inoculated into an adult human male during an envenoming bite. Results: The venom caused edema, an increase in muscle wet weight, and the degeneration of 20–35% of the underlying soleus muscle. Muscle fiber regeneration began at 4 days and was complete by 8 weeks. There was little evidence of either post- or presynaptic toxicity. Conclusions: The dominant effect of this venom in mammals is myotoxicity.

Publication metadata

Author(s): Hart AJ, Hodgson WC, Scott-Davey T, Harris JB

Publication type: Article

Publication status: Published

Journal: Muscle and Nerve

Year: 2011

Volume: 43

Issue: 4

Pages: 552-559

Print publication date: 08/02/2011

ISSN (print): 0148-639X

ISSN (electronic): 1097-4598

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/mus.21916

DOI: 10.1002/mus.21916

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