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Biologically defined risk groups can be used to define the impact of thalidomide maintenance therapy in newly diagnosed multiple myeloma

Lookup NU author(s): Professor Graham Jackson

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Abstract

Maintenance therapy is an attractive strategy for patients with multiple myeloma. However, the impact of maintenance thalidomide according to the underlying biology of the disease is still a matter of debate, with some studies suggesting that thalidomide is more beneficial in high risk disease, whilst others show the opposite. Biological risk groups defined by interphase fluorescence in situ hybridization (FISH) are powerful predictors of outcome. In this report we investigated the effect of maintenance thalidomide in different biological risk groups defined by different FISH categories. Our data show that maintenance thalidomide improves outcome in patients with biologically low risk disease, defined by the absence of adverse cytogenetic lesion or by the presence of hyperdiploidy alone. Conversely, thalidomide maintenance is detrimental for the overall survival of patients with biological high risk. We conclude that it is important to identify biologically low risk patients who will benefit from a maintenance strategy with thalidomide.

Publication metadata

Author(s): Brioli A, Kaiser MF, Pawlyn C, Wu P, Gregory WM, Owen R, Ross FM, Jackson GH, Cavo M, Davies FE, Morgan GJ

Publication type: Article

Publication status: Published

Journal: Leukemia & Lymphoma

Year: 2013

Volume: 54

Issue: 9

Pages: 1975-1981

Print publication date: 01/09/2013

ISSN (print): 1042-8194

ISSN (electronic): 1029-2403

Publisher: Informa Healthcare

URL: http://dx.doi.org/10.3109/10428194.2012.760736

DOI: 10.3109/10428194.2012.760736

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