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Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target

Lookup NU author(s): Dr Luca Miele, Professor Chris Day

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Abstract

There is increasing evidence for a correlation between intestinal microbiota, bacterial translocation and hepatic steatosis. Intestinal microbiota affects nutrient absorption and energy homeostasis. Altered intestinal permeability may favor the passage of bacteria-derived compounds into systemic circulation, causing a systemic inflammatory state, characteristic of the metabolic syndrome. The interaction between intestinal permeability and luminal bacteria is involved in the pathogenesis and evolution of non-alcoholic liver disease. Microbiota pharmacological modulation could be a promising tool for a new therapeutical approach to non-alcoholic fatty liver disease.

Publication metadata

Author(s): Miele L, Marrone G, Lauritano C, Cefalo C, Gasbarrini A, Day C, Grieco A

Publication type: Article

Publication status: Published

Journal: Current Pharmaceutical Design

Year: 2013

Volume: 19

Issue: 29

Pages: 5314-5324

Print publication date: 31/08/2013

ISSN (print): 1381-6128

ISSN (electronic): 1873-4286

Publisher: Bentham Science Publishers Ltd

URL: http://dx.doi.org/10.2174/1381612811319290011

DOI: 10.2174/1381612811319290011

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