ePrints

Socioeconomic inequalities in lung cancer treatment: systematic review and meta-analysis

Lookup NU author(s): Dr Lynne Forrest, Dr Jean Adams, Dr Helen Wareham, Emeritus Professor Greg RubinORCiD, Professor Martin White

Downloads

• Published version [.pdf]

Abstract

BackgroundIntervention-generated inequalities are unintended variations in outcome that result from the organisation and delivery of health interventions. Socioeconomic inequalities in treatment may occur for some common cancers. Although the incidence and outcome of lung cancer varies with socioeconomic position (SEP), it is not known whether socioeconomic inequalities in treatment occur and how these might affect mortality. We conducted a systematic review and meta-analysis of existing research on socioeconomic inequalities in receipt of treatment for lung cancer.Methods and FindingsMEDLINE, EMBASE, and Scopus were searched up to September 2012 for cohort studies of participants with a primary diagnosis of lung cancer (ICD10 C33 or C34), where the outcome was receipt of treatment (rates or odds of receiving treatment) and where the outcome was reported by a measure of SEP. Forty-six papers met the inclusion criteria, and 23 of these papers were included in meta-analysis. Socioeconomic inequalities in receipt of lung cancer treatment were observed. Lower SEP was associated with a reduced likelihood of receiving any treatment (odds ratio [OR] = 0.79 [95% CI 0.73 to 0.86], p<0.001), surgery (OR = 0.68 [CI 0.63 to 0.75], p<0.001) and chemotherapy (OR = 0.82 [95% CI 0.72 to 0.93], p = 0.003), but not radiotherapy (OR = 0.99 [95% CI 0.86 to 1.14], p = 0.89), for lung cancer. The association remained when stage was taken into account for receipt of surgery, and was found in both universal and non-universal health care systems.ConclusionsPatients with lung cancer living in more socioeconomically deprived circumstances are less likely to receive any type of treatment, surgery, and chemotherapy. These inequalities cannot be accounted for by socioeconomic differences in stage at presentation or by differences in health care system. Further investigation is required to determine the patient, tumour, clinician, and system factors that may contribute to socioeconomic inequalities in receipt of lung cancer treatment.

Publication metadata

Author(s): Forrest L, Adams J, Wareham H, Rubin G, White M

Publication type: Article

Publication status: Published

Journal: PLoS Medicine

Year: 2013

Volume: 10

Issue: 2

Print publication date: 05/02/2013

Date deposited: 17/04/2013

ISSN (electronic): 1549-1676

Publisher: Public Library of Science

URL: http://dx.doi.org/10.1371/journal.pmed.1001376

DOI: 10.1371/journal.pmed.1001376

Altmetrics

Funding

Share