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Investigating templating within Polymer-Scaffolded Dynamic Combinatorial Libraries

Lookup NU author(s): Clare Mahon, Alex Jackson, Dr Ben Murray, Professor David Fulton

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Abstract

Polymer-Scaffolded Dynamic Combinatorial Libraries (PS-DCLs) have been prepared in aqueous solution bythe reversible conjugation of two different acylhydrazide residues onto aldehyde-functionalizeddimethylacrylamide-based polymer scaffolds. PS-DCLs have been shown by 1H NMR spectroscopicanalysis to adapt their composition in response to addition of three macromolecular template species,namely poly(sodium-4-styrenesulfonate), bovine serum albumin and bovine trypsin. Compositionalchanges within PS-DCLs in response to template addition may be rationalized in terms of multivalentinteractions between members of the PS-DCL and templates. A systematic evaluation of how propertiesof the polymer scaffold, including molecular weight and density of aldehyde functionalities, affect thebehaviour of resultant PS-DCLs is detailed. Increasing the molecular weight of the polymer scaffold hasbeen shown to induce a linear decrease in the amplification of the preferred residue upon templateaddition. A linear relationship between the molar weight percentage of the aldehyde functionalizedmonomer and the extent of amplification of the preferred residue upon template addition has alsobeen demonstrated.

Publication metadata

Author(s): Mahon CS, Jackson AW, Murray BS, Fulton DA

Publication type: Article

Publication status: Published

Journal: Polymer Chemistry

Year: 2013

Volume: 4

Pages: 368–377

Print publication date: 11/09/2012

ISSN (print): 1759-9954

ISSN (electronic): 1759-9962

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/c2py20600e

DOI: 10.1039/c2py20600e

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