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Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family

Lookup NU author(s): Professor Roger Griffin

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Abstract

Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase ( PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents. (C) 2012 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Finlay MRV, Griffin RJ

Publication type: Article

Publication status: Published

Journal: Bioorganic & Medicinal Chemistry Letters

Year: 2012

Volume: 22

Issue: 17

Pages: 5352-5359

Print publication date: 01/09/2012

ISSN (print): 0960-894X

ISSN (electronic): 1464-3405

Publisher: Pergamon

URL: http://dx.doi.org/10.1016/j.bmcl.2012.06.053

DOI: 10.1016/j.bmcl.2012.06.053

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