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Lookup NU author(s): Professor Janet Quinn
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Candida albicans is an opportunistic pathogen and is recognised and phagocytosed by macrophages. Using live-cell imaging, non-lytic expulsion/exocytosis of C. albicans from macrophages is demonstrated for the first time. Following complete expulsion, both the phagocyte and pathogen remain intact and viable. Partial engulfment of hyphal C albicans without macrophage lysis is also demonstrated. These observations underpin the complexity of interactions between C. albicans and innate immune cells. (C) 2012 Elsevier Inc. All rights reserved.
Author(s): Bain JM, Lewis LE, Okai B, Quinn J, Gow NAR, Erwig LP
Publication type: Article
Publication status: Published
Journal: Fungal Genetics and Biology
Year: 2012
Volume: 49
Issue: 9
Pages: 677-678
Print publication date: 01/09/2012
ISSN (print): 1087-1845
ISSN (electronic): 1096-0937
Publisher: Academic Press
URL: http://dx.doi.org/10.1016/j.fgb.2012.01.008
DOI: 10.1016/j.fgb.2012.01.008
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