Toggle Main Menu Toggle Search

Open Access padlockePrints

Vitamin D in children with cystic fibrosis

Lookup NU author(s): Dr Malcolm Brodlie, Dr Matthew Thomas, Dr David Spencer

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Purpose The Cystic Fibrosis Trust in 2007 published a recommended target of 75-150 nmol/L for 25-hydroxyvitamin D (25-OHD). In 2008 we found that only 10% of pancreatic insufficient (PI) children met this target. An increase in supplementation was implemented and a repeat audit performed in 2010.Methods PI children ≥1 year under sole-care in our regional centre were included. Vitamin D3 supplementation increased by >450% to either 3800 IU/day liquid or 800 IU daily plus 20,000 IU weekly tablets. In 2010 pancreatic sufficient (PS) children were also audited separately.Results The median 25-OHD level increased from 51.5 nmol/L in 2008 (n=78, 10% >75 nmol/L) to 72 nmol/L in 2010 (n=72, 51% >75 nmol/L), p<0.0001. In PS children (n=15 in 2010) 87% had 25-OHD levels <75 nmol/L.Conclusions A substantial increase in supplementation led to a significant increase in 25-OHD levels but around half still failed to reach the recommended target.


Publication metadata

Author(s): Brodlie M, Orchard WA, Reeks GA, Pattman S, McCabe H, O'Brien CJ, Thomas MF, Spencer DA

Publication type: Article

Publication status: Published

Journal: Archives of Disease in Childhood

Year: 2012

Volume: 97

Issue: 11

Pages: 982-984

Print publication date: 04/08/2012

ISSN (print): 0003-9888

ISSN (electronic): 1468-2044

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/archdischild-2011-301398

DOI: 10.1136/archdischild-2011-301398


Altmetrics

Altmetrics provided by Altmetric


Funding

Funder referenceFunder name
G0800419Medical Research Council

Share