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Inhibition of the cell cycle with chemical inhibitors: A targeted approach

Lookup NU author(s): Professor Jane Endicott

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Abstract

Genetic links between deregulation of the cell cycle and cancer are well established. There have been significant recent developments both in our understanding of the molecular mechanisms that control cell cycle progression and in methods for protein structure determination at atomic resolution. These advances have allowed the rational design of small molecules that modulate the cell cycle by competing for sites of protein - protein or protein - ATP interactions. There is considerable optimism that these compounds, a selection of which are here reviewed, will become clinically significant drugs. © 2005 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Welburn JPI, Endicott JA

Publication type: Review

Publication status: Published

Journal: Seminars in Cell & Developmental Biology

Year: 2005

Volume: 16

Issue: 3

Pages: 369-381

ISSN (print): 1084-9521

ISSN (electronic): 1096-3634

Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

URL: http://dx.doi.org/10.1016/j.semcdb.2005.02.008

DOI: 10.1016/j.semcdb.2005.02.008

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