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Lookup NU author(s): Professor Michael Griffin, Dr Peter Lamb, Dr David Richardson, Dr Daya Karat, Nick Hayes
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Background: About 10 per cent of patients undergoing radical oesophagectomy for transmural (T3) carcinoma with lymph node involvement (N1) develop symptomatic bone metastases within 12 months of surgery. The aim of this study was to evaluate the introduction of targeted preoperative bone scintigraphy. Methods: Of 790 patients with oesophageal carcinoma staged between December 2000 and December 2004, 189 were eligible for potentially curative treatment. Tc-99m-labelled hydroxymethylene diphosphonate bone scintigraphy was performed in those with stage T3 N1 disease (identified by computed tomography and endoscopic ultrasonography) who were suitable for radical treatment. Results: A total of 115 patients had bone scintigraphy. The histological diagnosis was adenocarcinoma in 82 patients and squamous cell carcinoma in 33. Bone scintigraphy was normal or showed degenerative changes in 93 patients, and abnormal requiring further investigation in 22. Plain radiography, magnetic resonance imaging and biopsy confirmed the presence of bone metastases in 11 patients (9-6 per cent). Conclusion: Bone is frequently the first site of identifiable distant metastatic spread, and bone scintigraphy is recommended to exclude metastatic disease before radical treatment of advanced oesophageal carcinoma.
Author(s): Jennings NA, Griffin SM, Lamb PJ, Preston S, Richardson D, Karat D, Hayes N
Publication type: Article
Publication status: Published
Journal: British Journal of Surgery
Year: 2008
Volume: 95
Issue: 7
Pages: 840-844
ISSN (print): 0007-1323
ISSN (electronic): 1365-2168
Publisher: John Wiley & Sons Ltd.
URL: http://dx.doi.org/10.1002/bjs.6175
DOI: 10.1002/bjs.6175
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