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Circuits and brain rhythms in schizophrenia: a wealth of convergent targets

Lookup NU author(s): Professor Miles Whittington, Dr Anita Roopun

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Abstract

Few common neurological illnesses trace back to single molecular disturbances. Many disparate putative causes may co-associate with a single disease state. However, uncovering functional, hierarchical networks of underlying mechanisms can provide a framework in which many primary pathologies converge on more complex, single higher level correlates of disease. This article focuses on cognitive deficits associated with schizophrenia to illustrate: a) How non-invasive EEG biomarkers of cognitive function constitute such a 'higher level correlate' of underlying pathologies. b) How derangement of multiple, cell-specific, molecular processes can converge on such EEG-visible, correlates of disrupted cognitive function. This approach suggests that evidence-based design of multitarget therapies may take advantage of hierarchical patterns of convergence to improve both efficacy and selectivity of disease-intervention.

Publication metadata

Author(s): Whittington MA, Roopun AK, Traub RD, Davies CH

Publication type: Article

Publication status: Published

Journal: Current Opinion in Pharmacology

Year: 2011

Volume: 11

Issue: 5

Pages: 508-514

Print publication date: 07/05/2011

ISSN (print): 1471-4892

ISSN (electronic): 1471-4973

Publisher: Elsevier Ltd

URL: http://dx.doi.org/10.1016/j.coph.2011.04.010

DOI: 10.1016/j.coph.2011.04.010

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