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Lookup NU author(s): Dr Stephen Ball
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In animal models, the secretion of the cardiac hormone, brain natriuretic peptide (BNP), and its closely related peptide, atrial natriuretic peptide (ANP), are stimulated by acute hypoxia. There is extensive human evidence for a rise in ANP under acute hypoxic conditions but very little evidence regarding the BNP response to acute hypoxia in humans. We therefore subjected seven healthy subjects to an acute hypobaric hypoxic stimulus to examine if BNP secretion increases rapidly. Significant hypoxaemia (mean nadir oxygen saturation 62.3%) was induced but no significant rise in BNP occurred. This suggests that either such acute hypoxaemia is well tolerated by the healthy human heart or it is not a stimulus for BNP secretion.
Author(s): Ball S; Woods D; Hooper T; Mellor A; Hodkinson P; Wakeford R; Peaston B; Green N
Publication type: Article
Publication status: Published
Journal: Journal of Physiological Sciences
Year: 2011
Volume: 61
Issue: 3
Pages: 217-220
Print publication date: 24/03/2011
ISSN (print): 1880-6546
ISSN (electronic): 1880-6562
Publisher: Springer Japan KK
URL: http://dx.doi.org/10.1007/s12576-011-0141-3
DOI: 10.1007/s12576-011-0141-3
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