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Structure and segregation of the bacterial nucleoid

Lookup NU author(s): Dr Ling Juan Wu

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Abstract

In bacteria, chromosome segregation and DNA replication occur concurrently and there is no clear equivalent of a eukaryote mitotic spindle. Chromosome segregation can be viewed as a two-step process. As the first step, the origin of replication regions are segregated actively, probably by a mechanism involving an as yet unidentified motor protein or proteins, and held in position. The second step is the separation and migration of the rest of the chromosome probably driven by forces generated from various cellular processes such as DNA replication, transcription and transertion.

Publication metadata

Author(s): Wu LJ

Publication type: Article

Publication status: Published

Journal: Current Opinion in Genetics & Development

Year: 2004

Volume: 14

Issue: 2

Pages: 126-132

ISSN (print): 0959-437X

ISSN (electronic): 1879-0380

Publisher: Elsevier

URL: http://dx.doi.org/10.1016/j.gde.2004.01.006

DOI: 10.1016/j.gde.2004.01.006

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