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Breast cancer: Role of neoadjuvant therapy

Lookup NU author(s): Ish Ahmed, Professor Thomas Lennard

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Abstract

Breast cancer is now considered to be a systemic disease from the outset, with no correlation seen between the intensity of local treatment and survival or recurrence. Adjuvant therapy has clearly demonstrated a reduction in local and distant relapse; neoadjuvant therapy is similarly being assessed. It aims to treat occult metastases and decrease tumour bulk. Its use has demonstrated down-staging of the tumour with increased rates of breast-conserving surgery. Though neoadjuvant therapy seems to be associated with an increase in loco-regional recurrence compared to adjuvant therapy, no overall difference in survival has been demonstrated. This paper reviews several trials that compare neoadjuvant to adjuvant therapy, and the controversies around managing the axilla in the neoadjuvant setting. © 2009 Surgical Associates Ltd.

Publication metadata

Author(s): Ahmed M, Lennard T

Publication type: Review

Publication status: Published

Journal: International Journal of Surgery

Year: 2009

Volume: 7

Issue: 5

Pages: 416-420

ISSN (print): 1743-9191

ISSN (electronic): 1743-9159

URL: http://dx.doi.org/10.1016/j.ijsu.2009.06.001

DOI: 10.1016/j.ijsu.2009.06.001

PubMed id: 19524705

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