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Lookup NU author(s): Professor Muzlifah Haniffa, Professor Matthew CollinORCiD
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Mesenchymal stem cells are adherent stromal cells, initially isolated from the bone marrow, characterized by their ability to differentiate into mesenchymal tissues such as bone, cartilage and fat. They have also been shown to suppress immune responses in vitro. Because of these properties, mesenchymal stem cells have recently received a very high profile. Despite the dramatic benefits reported in early phase clinical trials, their functions remain poorly understood. Particularly, several questions remain concerning the origin of mesenchymal stem cells and their relationship to other stromal cells such as fibroblasts. Whereas clear gene expression signatures are imprinted in stromal cells of different anatomical origins, the anti-proliferative effects of mesenchymal stem cells and fibroblasts and their potential to differentiate appear to be common features between these two cell types. In this review, we summarize recent studies in the context of historical and often neglected stromal cell literature, and present the evidence that mesenchymal stem cells and fibroblasts share much more in common than previously recognized. ©2009 Ferrata Storti Foundation.
Author(s): Haniffa MA, Collin MP, Buckley CD, Dazzi F
Publication type: Review
Publication status: Published
Journal: Haematologica
Year: 2009
Volume: 94
Issue: 2
Pages: 258-263
ISSN (print): 0390-6078
ISSN (electronic): 1592-8721
URL: http://dx.doi.org/10.3324/haematol.13699
DOI: 10.3324/haematol.13699
