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CCR5 as a potential therapeutic target in multiple sclerosis

Lookup NU author(s): Dr Don Mahad

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Abstract

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. A number of chemokines and their receptors are implicated in the pathogenesis of MS. CCR5 is expressed on mononuclear inflammatory cells and its ligands are detectable in MS lesions and upregulated in the cerebrospinal fluid of MS patients. Furthermore, CCR5 appears to play an important role in the transmigration of leukocytes across the blood-brain barrier. We review the evidence implicating CCR5 in the pathogenesis of MS and discuss CCR5 antagonists as potential therapeutic agents in MS. Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.

Publication metadata

Author(s): Mahad D, Ransohoff RM

Publication type: Review

Publication status: Published

Journal: Drugs of the Future

Year: 2008

Volume: 33

Issue: 8

Pages: 705-709

ISSN (print): 0377-8282

ISSN (electronic):

URL: http://dx.doi.org/10.1358/dof.2008.033.08.122856

DOI: 10.1358/dof.2008.033.08.122856

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