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Lookup NU author(s): Richard Banks, Dr Jason Steggles
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To understand the function of genetic regulatory networks in the development of cellular systems, we must not only realise the individual network entities, but also the manner by which they interact. Multi-valued networks are a promising qualitative approach for modelling such genetic regulatory networks, however, at present they have limited formal analysis techniques and tools. We present a flexible formal framework for modelling and analysing multi-valued genetic regulatory networks using high-level Petri nets and logic minimization techniques. We demonstrate our approach with a detailed case study in which part of the genetic regulatory network responsible for the carbon starvation stress response in Escherichia coli is modelled and analysed. We then compare and contrast this multi-valued model to a corresponding Boolean model and consider their formal relationship.
Author(s): Banks R, Steggles LJ
Publication type: Article
Publication status: Published
Journal: Journal of Integrative Bioinformatics
Year: 2007
Volume: 4
Issue: 3
Pages: 60
Print publication date: 01/01/2007
ISSN (electronic): 1613-4516
Publisher: Bielefeld University, Bioinformatics Department
URL: http://journal.imbio.de/articles/pdf/jib-60.pdf
Notes: Special issue: 4th Integrative Bioinformatics Workshop, Gent, Belgium, 2007