ePrints

Reduced intensity conditioning for hematopoietic stem cell transplantation: has it achieved all it set out to?

Lookup NU author(s): Brie Turner, Professor Matthew CollinORCiD

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

At its inception, reduced intensity conditioning (RIC) was heralded as a means to limit toxicity after hematopoietic stem cell transplantation (HSCT), especially for the older patient demographic. The aim was to promote the inherent anti-leukemic activity of the transplant whilst reducing toxicity and transplant-related mortality (TRM). More than 10 years on, much has been learnt about the role of conditioning in determining outcomes after transplantation. The use of RIC as a preparative regimen has increased the number of patients that can benefit from HSCT because the initial therapy is less toxic. However, many of the early pioneers of RIC quickly realized that the toxicity from graft-versus-host disease (GvHD) was equally as potent as that from conditioning. Furthermore, questions remain concerning the efficacy of RIC regimens in retaining anti-leukemic immunity, especially in cases of aggressive disease. The undoubted synergy between chemotherapeutic and immunologic treatment of malignancy means that reduction of conditioning intensity to minimal levels may not be entirely logical.

Publication metadata

Author(s): Turner BE, Collin M, Rice AM

Publication type: Review

Publication status: Published

Journal: Cytotherapy

Year: 2010

Volume: 12

Issue: 4

Pages: 440-454

Print publication date: 01/07/2010

ISSN (print): 1465-3249

ISSN (electronic): 1477-2566

Publisher: TAYLOR & FRANCIS AS

URL: http://dx.doi.org/10.3109/14653241003709678

DOI: 10.3109/14653241003709678

Share