Browse by author
Lookup NU author(s): Dr Angela Pyle, Professor Mark Walker, Professor Patrick Chinnery, Dr Simon Baudouin
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background: Insulin resistance and hyperglycaemia are common in severe sepsis. Mitochondrial uncoupling protein 2 (UCP2) plays a role in insulin release and sensitivity. Objectives: To determine if a common, functional polymorphism in the UCP2 gene promoter region (the 2866 G/A polymorphism) contributes to the risk of hyperglycaemia in severe sepsis. Results: In the prospective group 120 non-diabetic patients who were carriers of the G allele had significantly higher maximum blood glucose recordings than non-carriers (mean (SD) AA 8.5 (2.2) mmol/l; GA 8.5 (2.4) mmol/l; GG 10.1 (3.1) mmol/l; p=0.0042) and required significantly more insulin to maintain target blood glucose (p=0.0007). In the retrospective study 103 non-diabetic patients showed a similar relationship between maximum glucose and UCP genotype (AA 6.8 (2.3) mmol/l; GA 7.8 (2.2) mmol/l; GG 9.2 (2.9) mmol/l; p=0.0078). Conclusions: A common, functional polymorphism in the promoter region of the UCP2 gene is associated with hyperglycaemia and insulin resistance in severe sepsis. This has implications for our understanding of the genetic pathophysiology of sepsis and is of use in the stratification of patients for more intensive management.
Author(s): Pyle A, Ibbett IM, Gordon C, Keers SM, Walker M, Chinnery PF, Baudouin SV
Publication type: Article
Publication status: Published
Journal: Journal of Medical Genetics
Year: 2009
Volume: 46
Issue: 11
Pages: 773-775
ISSN (print): 0022-2593
ISSN (electronic): 1468-6244
Publisher: BMJ Group
URL: http://dx.doi.org/10.1136/jmg.2009.067173
DOI: 10.1136/jmg.2009.067173
Altmetrics provided by Altmetric