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Lookup NU author(s): Paul Wright
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Cancer is a common disease in Western society that can affect any organ system. It has a high morbidity and mortality despite advances in treatment over the last hundred years. There is a clear need for new approaches to cancer chemotherapy including the possibility of reducing systemic adverse effects associated with current treatments. Vesicle trafficking is an essential cellular process that is perhaps not fully recognized. There is mounting evidence that vesicle trafficking, including the release of extracellular microvesicles, is a highly important process in tumorigenesis. Diverse aspects of tumourigenesis including invasion, metastasis, cell cycle regulation, angiogenesis, tumor immune privilege, neoplastic coagulopathy and multidrug resistance can be explained by altered vesicle trafficking in cancer cells. This paper reviews the evidence in the scientific and patent literature for the role of vesicle trafficking in tumourigenesis and suggests a number of targets and strategies that may be important for cancer therapeutics.
Author(s): Wright PK
Publication type: Review
Publication status: Published
Journal: Recent Patents on Anti-Cancer Drug Discovery
Year: 2008
Volume: 3
Issue: 2
Pages: 137-147
ISSN (print): 1574-8928
ISSN (electronic):
Publisher: BENTHAM SCIENCE PUBL LTD
URL: http://dx.doi.org/10.2174/157489208784638730
DOI: 10.2174/157489208784638730
