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BuChE-K and APOE ε4 allele frequencies in Lewy body dementias, and influence of genotype and hyperhomocysteinemia on cognitive decline

Lookup NU author(s): Dr Christopher Morris, Dr Clive Ballard

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Abstract

Apolipoprotein E (APOE) epsilon 4 and butyrylcholinesterase-K (BuChE-K) are associated with an increased risk for Alzheimer's disease. The primary objective was to evaluate frequencies of these alleles in dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD). A secondary objective was to evaluate influences on rate of cognitive decline. This analysis used data from participants consenting to pharmacogenetic testing in placebo-controlled rivastigmine studies. Allele frequencies in DLB and PDD were compared using logistic regression. Within the PDD placebo sample. associations with cognitive decline were evaluated (the DLB sample was too small for these evaluations). Fifty-seven DLB and 323 PDD subjects provided APOE and BuChE data. Allelic frequencies were higher in DLB, relative to PDD subjects, for BuChE-K (P = 0.06), APOE epsilon 4 (P

Publication metadata

Author(s): Lane R, He YS, Morris C, Leverenz JB, Emre M, Ballard C

Publication type: Article

Publication status: Published

Journal: Movement Disorders

Year: 2009

Volume: 24

Issue: 3

Pages: 392-400

Date deposited: 08/06/2010

ISSN (print): 0885-3185

ISSN (electronic): 1531-8257

Publisher: John Wiley & Sons, Inc.

URL: http://dx.doi.org/10.1002/mds.22357

DOI: 10.1002/mds.22357

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