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Regulated release of B cell-derived exosomes: Do differences in exosome release provide insight into different APC function for B cells and DC?

Lookup NU author(s): Dr Andrew Knight

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Abstract

The induction of CD4 T-H cell activity is a crucial component of the mammalian acquired immune response. in order to activate TH cells, pathogen-derived peptides are displayed on the plasma membrane of specialized cells termed APC. As well as unravelling common mechanisms in this process, considerable attention has been given to the distinct roles of the various cell types involved. in this issue of the European Journal of Immunology, a study examining the release by B cells of small vesicles termed exosomes is presented. This commentary reports that the control of exosome release from B cells appears to differ from that seen in DC. How these differences may relate to important features that differentiate the antigen presenting cell function of B cells and DC in vivo is also discussed.

Publication metadata

Author(s): Knight AM

Publication type: Article

Publication status: Published

Journal: European Journal of Immunology

Year: 2008

Volume: 38

Issue: 5

Pages: 1186-1189

Date deposited: 07/04/2011

ISSN (print): 0014-2980

ISSN (electronic): 1521-4141

Publisher: Wiley - VCH Verlag GmbH & Co. KGaA

URL: http://dx.doi.org/10.1002/eji.200838374

DOI: 10.1002/eji.200838374

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