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Lookup NU author(s): Professor John Mathers, Dr Jill McKay
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Whilst the primary DNA sequence sets the limits of potential gene expression, the pattern of gene expression in it given cell under particular circumstances is determined by several factors including the epigenetic marking of the genome. These marks include DNA methylation and post-translational modification of the histones around which DNA is wrapped when packaged in the nucleus. Importantly, these marks are malleable in response to environmental exposures and contribute to phenotypic plasticity in the context of a fixed genotype. There is now proof of principle that maternal diet can have a profound impact on the epigenome and so determine gene expression patterns and health throughout the life-course. Studies of altered epigenetic marking will be of profound importance for mechanistic understanding of the role of nutrition in health but especially for studies of the developmental origins of health.
Author(s): Mathers JC, Mckay JA
Editor(s): Koletzko B; Decsi T; Molnár D; de la Hunty A
Publication type: Conference Proceedings (inc. Abstract)
Publication status: Published
Conference Name: Early Nutrition Programming and Health Outcomes in Later Life: Obesity and Beyond
Year of Conference: 2009
Pages: 119-123
ISSN: 9781402091728
Publisher: Springer
Library holdings: Search Newcastle University Library for this item
ISBN:
