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Lookup NU author(s): Professor Nicholas JakubovicsORCiD, Professor Ruth Valentine
The ability to control intracellular levels of transition metals such as Mn2+, Fe2+ and Zn2+ is critical for the virulence of many pathogenic bacteria. In this issue of Molecular Microbiology, Rosch et al. describe the first identification of a Mn2+ efflux system in bacteria, MntE of Streptococcus pneumoniae, and demonstrate that it is required for virulence in an animal model. Disruption of the mntE gene leads to widespread transcriptional changes that are distinct from responses to extracellular Mn2+. These findings reveal, for the first time, that a bacterial trace metal efflux system plays a role in disease. Thus, MntE represents a new lead for the development of antimicrobials specifically aimed at disrupting microbial metal ion homeostasis.
Author(s): Jakubovics NS, Valentine RA
Publication type: Editorial
Publication status: Published
Journal: Molecular Microbiology
Year: 2009
Volume: 72
Issue: 1
Pages: 1-4
ISSN (print): 0950-382X
ISSN (electronic):
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1111/j.1365-2958.2009.06637.x
DOI: 10.1111/j.1365-2958.2009.06637.x