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Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease

Lookup NU author(s): Professor Johannes Attems

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Abstract

Neurofibrillary tangle predominant dementia (NFTPD) is a subset of late onset dementia, clinically different from traditional "plaque and tangle" Alzheimer disease (AD): later onset, shorter duration, less severe cognitive impairment, and almost absence of ApoE epsilon4. Neuropathology reveals abundant allocortical neurofibrillary pathology with no or few isocortical tau lesions, absence of neuritic plaques, absence or scarcity of amyloid deposits, but neurofibrillary changes comprising both 3 and 4 repeat (3R and 4R) tau immunohistochemistry are not significantly different from those in classical AD. Comparing 51 autopsy cases of NFTPD with 244 classical AD subjects, the nosology of NFTPD and its differences from AD are discussed.

Publication metadata

Author(s): Jellinger KA, Attems J

Publication type: Article

Publication status: Published

Journal: Acta Neuropathologica

Year: 2007

Volume: 113

Issue: 2

Pages: 107-117

ISSN (print): 0001-6322

ISSN (electronic): 1432-0533

Publisher: Springer

URL: http://dx.doi.org/10.1007/s00401-006-0156-7

DOI: 10.1007/s00401-006-0156-7

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