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Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study

Lookup NU author(s): Professor Johannes Attems

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Abstract

In a retrospective study of a consecutive autopsy series of 2060 elderly subjects (mean age 78.5 +/- 6.8 SD years), sporadic cerebral amyloid angiopathy (CAA) of various degrees was detected in 73.2% and in 98.5% of autopsy-confirmed cases of typical (plaque and tangle) Alzheimer disease (AD). Spontaneous (non-traumatic) intracerebral hemorrhages (ICH) (excluding microbleeds) were seen in 5.6% of the total cohort and in 7.2% of definite AD cases; CAA was found in 49% of brains without and in 48.7% with ICH which was not significantly different. The latter groups showed a significantly higher frequency of severe degrees of CAA than those without ICH (80.4 vs 30.9%, p

Publication metadata

Author(s): Attems J, Lauda F, Jellinger KA

Publication type: Article

Publication status: Published

Journal: Journal of Neurology

Year: 2008

Volume: 255

Issue: 1

Pages: 70-76

ISSN (print): 0340-5354

ISSN (electronic): 1432-1459

Publisher: Dr. Dietrich Steinkopff Verlag

URL: http://dx.doi.org/10.1007/s00415-008-0674-4

DOI: 10.1007/s00415-008-0674-4

Notes: Attems, Johannes Lauda, Florian Jellinger, Kurt A Research Support, Non-U.S. Gov't Germany Journal of neurology J Neurol. 2008 Jan;255(1):70-6. Epub 2008 Jan 18.

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