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Burkholderia cepacia complex genomovars and pulmonary transplantation outcomes in patients with cystic fibrosis

Lookup NU author(s): Professor Anthony De SoyzaORCiD, Professor John Dark, Katherine Gould

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Abstract

Burkholderia cepacia is a group of organisms that comprises seven genotypically distinct species (B cepacia genomovars I-VII), which are collectively known as the B cepacia complex. Preoperative infection with B cepacia Is associated with a poor prognosis in lung transplant recipients with cystic fibrosis. Many centres do not, therefore, offer transplants to these Individuals. Our aim was to ascertain whether or not post-transplant mortality is affected by pretransplant genomovar status. We studied archived isolates with PCR-based methods, and recorded excessive mortality in patients infected with B cepacia genomovar III, but not in those infected with other genomovars.

Publication metadata

Author(s): De Soyza A, McDowell A, Archer L, Dark JH, Elborn SJ, Mahenthiralingam E, Gould K, Corris PA

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2001

Volume: 358

Issue: 9295

Pages: 1780-1781

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(01)06808-8

DOI: 10.1016/S0140-6736(01)06808-8

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