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Lookup NU author(s): Dr Ian HardcastleORCiD, Meg Barber
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The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection of structurally diverse bromoalkanes. The use of ion-exchange resins during the reaction sequence enabled the preparation of the majority of the products in 82-98% purity without the need for chromatography. (C) 2001 Elsevier Science Ltd. All rights reserved.
Author(s): Hardcastle IR, Barber AM, Marriott JH, Jarman M
Publication type: Article
Publication status: Published
Journal: Tetrahedron Letters
Year: 2001
Volume: 42
Issue: 7
Pages: 1363-1365
ISSN (print): 0040-4039
ISSN (electronic): 1873-3581
URL: http://dx.doi.org/10.1016/S0040-4039(00)02252-8
DOI: 10.1016/S0040-4039(00)02252-8
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