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Chemotherapy in the management of infantile fibrosarcoma

Lookup NU author(s): Professor Archibald Malcolm, Emeritus Professor Alan Craft

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Abstract

Infantile fibrosarcoma (IF) has traditionally been treated with surgery, which may have considerable morbidity. Chemotherapy has been suggested in order to reduce the need for extensive surgery. Nine children with histologically confirmed IF who received chemotherapy are described. Six children were treated with chemotherapy initially, two following conservative surgery, and one following recurrence after surgery. All received vincristine (V) and actinomycin D (A), and six received additional drugs including ifosfamide (I), cyclophosphamide (C), adriamycin (Ad), etoposide (E), and cisplatinum (CDDP). Objective responses were achieved in eight: three responded completely (CR), two responded partially (PR), which allowed conservative surgery, one had stable disease, one had an initial PR, but subseqUently had tumour recurrence 1 month after cessation of treatment, necessitating further surgery and chemotherapy, and one had an initial PR but died following local and regional metastases. One child had no response to chemotherapy but is alive with stable residual disease. Thus, five of nine children achieved a CR-three with chemotherapy alone. With the inclusion of chemotherapy as part of their treatment, five children, for whom curative surgery may have resulted in amputation, remain alive with limbs intact. Chemotherapy including V and A should be given to infants with fibrosarcoma in whom curative surgery would be mutilating. (C) 1993 Wiley-Liss, Inc.


Publication metadata

Author(s): Kynaston, J. A., Malcolm, A. J., Craft, A. W., Davies, S. M., Jones, P. H. M., King, D. J., Mitchell, C. D., Oakhill, A., Stiller, C. A.

Publication type: Article

Publication status: Published

Journal: Medical and Pediatric Oncology

Year: 1993

Volume: 21

Issue: 7

Pages: 488-493

ISSN (print): 0098-1532

ISSN (electronic): 1545-5017

URL: http://dx.doi.org/10.1002/mpo.2950210706

DOI: 10.1002/mpo.2950210706

PubMed id: 8341216


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