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Lookup NU author(s): Kevin Fishwick, Lynsey Robson, Professor Alan Calvert
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Purpose: The aim of this study wets to increase the dose intensity of carboplatin in women with International Federation of Gynecology and Obstetrics (FIGO) Stage Ic-IV epithelial ovarian cancer with the use of granulocyte colony-stimulating factor (G-CSF; filgrastim; Amgen, Thousand Oaks, CA). Patients and Methods: A phase I study of escalating target erect under the curves (AUCs) of carboplatin with G-CSF (filgrastim) was undertaken. The target AUCs were 5 mg/mL.min every 21 days for four cycles, 5 mg/mL.min every 14 days for four cycles, 7 mg/mL.min every 14 days for four cycles, 9 mg/mL.min every 14 days for four cycles, and 11 mg/mL.min every 14 days for four cycles. G-CSF was given at a dose of 5 mu g/kg/d starting 24 hours after carboplatin administration and lasting until 24 hours before the next cycle and until day 14 after the last cycle. Results: We were able to escalate to an AUC level of 9 mg/mL.min every 14 days for four cycles. At this dose, severe thrombocytopenia, that necessitated dosage delays, and failure to give subsequent cycles of carboplatin were observed. We then reduced the AUC level to 8 mg/mL.min every 14 days for four cycles. However, severe thrombocytopenia was also observed at this level. Conclusion: An AUC of 7 mg/mL.min every 14 days for four cycles is the maximum tolerated AUC level that can be achieved with G-CSF. Further escalations may be possible using either combinations of cytokines or peripheral stem-cell collections.
Author(s): Lind, M. J., GhazalAswad, S., Gumbrell, L., Fishwick, K. A., Craigs, D., Millward, M. J., Bailey, N. P., DoreGreen, F., Chapman, F., Simmons, D., Proctor, M., Oakey, A., Robson, L., Middleton, I., McCann, E., Sinha, D., Calvert, A. H.
Publication type: Article
Publication status: Published
Journal: Journal of Clinical Oncology
Year: 1996
Volume: 14
Issue: 3
Pages: 800-805
Print publication date: 01/03/1996
ISSN (print): 0732-183X
ISSN (electronic): 1527-7755
URL: http://jco.ascopubs.org/cgi/content/abstract/14/3/800