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p53 expression in three separate tumours from a patient with Li-Fraumeni's syndrome

Lookup NU author(s): Emeritus Professor Alan Craft, Professor Archibald Malcolm

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Abstract

The Li-Fraumeni cancer syndrome is a rare autosomal dominant syndrome, characterised by the occurrence of diverse mesenchymal and epithelial neoplasms at multiple sites. It has recently been shown that some of these individuals have a germ line mutation of the p53 tumour suppressor gene. The case of one member of such a family who has now developed three separate primary malignant tumours is reported. All three tumours expressed mutant p53 protein.


Publication metadata

Author(s): King, P., Craft, A. W., Malcolm, A. J.

Publication type: Note

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 1993

Volume: 46

Issue: 7

Pages: 676-677

Print publication date: 01/07/1993

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146

URL: http://dx.doi.org/10.1136/jcp.46.7.676

DOI: 10.1136/jcp.46.7.676

PubMed id: 8157761


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