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Lookup NU author(s): Emeritus Professor Alan Craft, Dr Michael Reid
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Severe congenital neutropenia has a poor outlook. In vitro clonogenic assays using recombinant growth factors may improve understanding of the underlying pathogenetic mechanisms and identify those in whom growth factors might be clinically useful. Marrow from a boy with congenital neutropenia was cultured with a variety of recombinant growth factors. The results show that the neutropenia did not result from a lack of myeloid progenitors but that these progenitors could not produce mature neutrophils. Bone marrow transplantation is being considered as the most likely approach to correct neutropenia.
Author(s): Chang, J., Craft, A. W., Reid, M. M., Coutinho, L. H., Dexter, M.
Publication type: Article
Publication status: Published
Journal: American Journal of Hematology
Year: 1990
Volume: 35
Issue: 2
Pages: 125-126
Print publication date: 01/10/1990
ISSN (print): 0361-8609
ISSN (electronic): 1096-8652
URL: http://dx.doi.org/10.1002/ajh.2830350212
DOI: 10.1002/ajh.2830350212
PubMed id: 1698019
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